九州ku酷游登录页

九州ku酷游登录页-石贵阳-正高--

国家级重点学科

一级学科博士学位授予点

“双一流”建设学科

ENGLISH

师资队伍
Faculty and staff

邓禹

邓禹

职称:教授、博士生导师

学历/学位:研究生/博士

电话:13665117395

电子邮箱:dengyu@jiangnan.edu.cn

简介

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长期从事发酵工程,代谢工程,合成生物学,工业微生物等领域的研究,主要承担《细胞生物学》等课程的讲授工作。近5年来在Nucleic Acids Research, Biotechnology Advances, Metabolic Engineering等行业主流国际期刊发表SCI论文50余篇,申请发明专利40余项,其中授权25项;主持包括国家重点研发计划、国家自然基金等在内的国家及省部级科研项目10余项;江苏省杰出青年基金获得者、江苏省特聘教授、江苏省“双创人才”、江苏双创团队负责人、江苏省六大人才高峰、无锡市社会事业领军人才等荣誉称号。

学习工作经历

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工作经历

2015.1-现在:江南大学粮食发酵工艺与技术国家工程实验室,江苏特聘教授,江苏省双创人才,博士生导师, 代谢工程团队负责人;

 

2013.8-2014.12: 助理教授(Assistant Professor, 生物与农业工程系(Department of Biological and Agricultural Engineering), 美国堪萨斯州立大学(Kansas State University)

 

2011.5- 2013.6:博士后研究员(Postdoctoral Research Associate),Thayer工学院(Thayer School of Engineering),美国达特茅斯学院(Dartmouth College)。

 

学习经历

2007.8-2011.5: 美国弗吉尼亚联邦大学(Virginia Commonwealth University),化学与生命科学工程专业(Chemical and Life Science Engineering),工学博士导师:Dr. Stephen S. Fong, 教授;

 

2005.9-2007.6: 江南大学,九州ku酷游登录页, 发酵工程专业, 工学硕士,导师:陈坚,教授;

 

2001.9-2005.6:江南大学,生物工程专业,工学学士。


主要成果

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一、论文(论著)发表情况

部分代表性论文如下:

1.      Meng jia Wu, Junhua Di, Lei Gong, Yu-Cai He, Cuiluan Ma, Yu Deng*. Enhanced adipic acid production from sugarcane bagasse by a rapid room temperature pretreatment. Chemical Engineering Journal, (2022). https://doi.org/10.1016/j.cej.2022.139320. (IF=16.744)

2.      Shiyun Li, Wenxuan Fu, Ruifang Su, Yunying Zhao, Yu Deng*. Metabolic engineering of the malonyl-CoA pathway to efficiently produce malonate in Saccharomyces cerevisiae. Metabolic Engineering. 2022 May 25;73:1-10. doi: 10.1016/j.ymben.2022.05.007. Online ahead of print. (IF=8.829)

3.      Shenghu Zhou, Hal S Alper, Jingwen Zhou, Yu Deng*. Intracellular biosensor-based dynamic regulation to manipulate gene expression at the spatiotemporal level. Critical Reviews in Biotechnology. 2022, DOI: 10.1080/07388551.2022.2040415 (IF=9.062)

4.      Shiyun Li, Lizhou Ma, Wenxuan Fu, Ruifang Su, Yunying Zhao, Yu Deng*. A programmable synthetic upstream activating sequence library for fine-tuning gene expression levels in Saccharomyces cerevisiae. ACS synthetic Biology. 2022, 18;11(3):1228-1239. (IF=5.249).

5.      Mei Zhao, Zhenqi Yuan, Longtao Wu, Shenghu Zhou, Yu Deng*. Precise prediction of promoter strength based on a de novo synthetic promoter library coupled with machine learning. ACS synthetic Biology. 2022, 11(1):92-102. (IF=5.249).

6.      Shenghu Zhou, ShuoFu Yuan, Priya H. Nair, Hal S. Alper, Yu Deng*, Jingwen Zhou*. Development of a growth coupled and multi-layered dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin biosynthesis in Escherichia coli. Metabolic Engineering. 2021, 67:41-52. (IF=8.829).

7.      Yunying Zhao, Shiyun Li, Jing Wang, Yingli Liu, Yu Deng*. Roles of high osmolarity glycerol and cell wall integrity pathways in cadmium toxicity in Saccharomyces cerevisiae. International Journal of Molecular Sciences. 2021, 22(12):6169. (IF=6.208).

8.      Nana Ding, Shenghu Zhou, Yu Deng*. Transcription factor-based biosensor engineering for applications in synthetic biology. ACS synthetic Biology. 2021, 10(5):911-922. (IF=5.249).

9.      Shumin Xu, Linpei Zhang, Shenghu Zhou, Yu Deng*. (2021) Biosensor-based multi-genetic pathway optimization for enhancing the production of glycolate. Applied and Environmental Microbiology. 2021, 87(12):e0011321. (IF=5.005)

10.   Tingting Hao, Guohui Li, Shenghu Zhou*, Yu Deng*. Engineering the reductive TCA pathway to dynamically regulate the biosynthesis of adipic acid in Escherichia coli. ACS Synthetic Biology. 2021, 10(3):632-639. (IF=5.249)

11.   Nana Ding, Zhenqi Yuan, Xiaojuan Zhang, Jing Chen, Shenghu Zhou, Yu Deng*. Programmable cross-ribosome-binding sites to fine-tune the dynamic range of transcription factor-based biosensor. Nucleic acids research. 2020, 48(18):10602-10613. (IF=19.160)

12.   Shenghu Zhou, Tingting Hao, Shumin Xu, Yu Deng*. Coenzyme A thioester-mediated carbon chain elongation as a paintbrush to draw colorful chemical compounds. Biotechnology Advances. 2020, 43:107575. (IF=17.681)

13.   Li Wang, Guohui Li, Yu Deng*. Biosynthesis of diamines: research progress and application prospects. Applied and Environmental Microbiology, 2020, 86(23):e01972-20. (IF=5.005)

14.   Xi Zhang, Yunying Zhao, Yingli Liu, Jing Wang, Yu Deng*. Recent progress on bio-based production of dicarboxylic acids in yeast. Applied Microbiology and Biotechnology. 2020, 104: 4259-4272. (IF=5.560)

15.   Lixia Liu, Shenghu Zhou, Yu Deng*. 3-Ketoacyl-CoA thiolase: an engineer enzyme for carbon chain elongation of chemical compounds. Applied Microbiology and Biotechnology. 2020, 104(19):8117-8129. (IF=5.560)

16.   Guohui Li, Dixuan Huang, Xue Sui, Shiyun Li, Bing Huang, Xiao-Juan Zhang, Hui Wu, Yu Deng*. Advances in microbial production of medium-chain dicarboxylic acids for nylon materials. Reaction Chemistry & Engineering. 2020, 5(2): 221-238. (IF=5.200).

17.   Liying Ruan, Lu Li, Dian Zou, Cong Jiang, Zhiyou Wen, Shouwen Chen, Yu Deng*. Xuetuan Wei*. Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle. Biotechnology for Biofuels. 2019, 12:211. (IF=7.670).

18.   Yuqing Tian, Yu Deng*, Wenli Zhang*, Wanmeng Mu. Sucrose isomers as alternative sweeteners: properties, production, and applications. Applied Microbiology and Biotechnology. 2019, 103(21-22):8677-8687. (IF=5.560).

19.   Kangjia Zhu, Guohui Li, Ren Wei, Yin Mao, Yunying Zhao, Aiyong He, Zhonghu Bai, Yu Deng*. Systematic analysis of the effects of different nitrogen source and ICDH knockout on glycolate synthesis in Escherichia coli. Journal of Biological Engineering, 2019, 13 (1), 30 (IF= 6.248)

20.   Mei Zhao, Dixuan Huang, Xiaojuan Zhang, Mattheos A.G. Koffas, Jingwen Zhou, Yu Deng*. Metabolic engineering of Escherichia coli for producing adipic acid through the reverse adipate-degradation pathway. Metabolic Engineering, 2018, 47:254-262. (IF =8.829)

21.   Yu Deng*, Ning Ma, Kangjia Zhu, Xuetuan Wei*, Yunying Zhao. Balancing the carbon flux distributions between the TCA cycle and glyoxylate shunt to produce glycolate at high yield and titer in Escherichia coli. Metabolic Engineering, 2018, 46: 28-34. (IF = 8.829)

22.   Na Chen, Jingya Wang, Yunying Zhao and Yu Deng*. Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer. Microbial Cell factories, 2018, 17:67. (IF = 6.352)

23.   Mei Zhao, Guohui Li, Yu Deng*. Engineering Escherichia coli for glutarate production as the C5 platform backbone. Applied and Environmental Microbiology, 2018, 84:e00814-18. (IF= 5.005).

24.   Yu Deng*, Xi Zhang, Xiaojuan Zhang. Recent advances in genetic modification systems for Actinobacteria. Applied Microbiology and Biotechnology, 2017, 101(6):2217-2226. (IF= 5.560).

25.   Yu Deng*, Adam Fisher, Stephen Fong. Systematic analysis of intracellular mechanisms of propanol production in the engineered Thermobifida fusca B6 strain. Applied Microbiology and Biotechnology, 2015, 99: 8089-8100. (IF=5.560)

 

二、专利情况

1      邓禹,张晓娟,毛银。一种己二酸的全生物合成方法,ZL201510369975.6,2018/8/28

2      邓禹,张晓娟,邹宗胜,周彤。一种植物乳杆菌发酵豆粕的方法,ZL201610399010.6,     2019/8/23

3      邓禹,赵梅,毛银,赵运英,卢伟强,陆春波。一种从发酵液中提取己二酸的方法,    ZL201710622975.1,2019/9/3

4      邓禹,陆春波,毛银,赵运英。一株乳酸片球菌及其应用,ZL201710585894.9,     2019/9/3

5      邓禹,陆春波,毛银,赵运英。一株副干酪乳杆菌及其应用,ZL201710585895.3,     2019/9/3

6      邓禹,杨菊,张晓娟,赵运英,毛银。一种5-羰基-2-戊烯酰基辅酶A还原酶突变体,    ZL201710623724.5,2019/9/17

7      邓禹,卢伟强,张晓娟,毛银。一株快速降解污水中氮素的菌株及其应用,    ZL201710139452.1,2019/10/8

8      邓禹,卢伟强,张晓娟,赵运英,毛银。一株小球藻及其在降解污水中的应用,    ZL201710565200.5,2019/10/8

9      邓禹,邹宗胜,赵运英,毛银。一株植物乳杆菌及其在发酵饲料方面的应用,        ZL201710749942.3,2019/11/19

10    邓禹,张晓娟,马宁。一种无基因敲除提高大肠杆菌中乙醇酸产率的方法,    ZL201610480579.5,2019/12/17

11    邓禹,赵梅,毛银,张晓娟,黄荻萱。一种提高大肠杆菌中己二酸产量的方法,    ZL201710117371.1,2020/2/18

12    邓禹,陈娜,张晓娟,毛银。一种构建重组酿酒酵母发酵生产葡萄糖二酸的方法,        ZL201710280402.5,2020/9/18

13    邓禹,赵梅,赵运英,毛银,周宇,隋雪,黄荻萱。一种产己二酸的大肠杆菌重组菌及其应用,ZL201711138990.5,2020/12/29

14    邓禹,陈娜,张晓娟,赵运英,毛银。一种提高酿酒酵母工程菌株发酵生产葡萄糖二酸的方法,ZL201810091278.2,2020/8/27

15    邓禹,朱康佳,李国辉,毛银,赵运英。一种快速检测大肠杆菌中乙醇酸产量的方法,        ZL2018114934151,2020/8/4

16    邓禹,马宁,张晓娟,赵运英,毛银。一种提高大肠杆菌中乙醇酸产率的方法,    ZL201810105170.4,2021/2/26

17 邓禹,赵梅,张熙,黄荻萱,毛银。一种戊二酸的全生物合成的方法,ZL201710512583.X,2021/7/27

18 邓禹,毛银,卫亚峰,陆春波,李国辉,赵运英,周胜虎。一种提高梭热杆菌纤维素酶酶活发酵方法,ZL2019109429091,2021/9/30

19 邓禹,李国辉,黄荻萱,毛银,赵运英,周胜虎。一种精确检测发酵液中丁二胺含量的方法,ZL201911179043X,2021/8/18

20 邓禹,李国辉,王莉,黄荻萱,毛银,赵运英,周胜虎。一种精确检测发酵液中戊二胺含量的方法,ZL2019111793832,2021/8/18

21 邓禹,赵运英,李杰,李国辉,毛银,周胜虎。一种提高酿酒酵母工程菌株合成葡萄糖二酸效率的方法,ZL2019114128234,2021/10/26

22 邓禹,李国辉,王莉,毛银,赵运英,周胜虎。一种精确检测发酵液中己二胺含量的方法,ZL2020102596467,2021/8/18

23 邓禹,徐淑敏,周胜虎,毛银,李国辉,赵运英。一种可反复消除的乙醇酸传感器及其构建方法,ZL2019109725521,2022/1/11

24 邓禹,赵运英,李杰,毛银,周胜虎,李国辉。一种提高酿酒酵母工程菌生产葡萄糖二酸的发酵方法,ZL2019114128643,2022/2/8

25 邓禹,赵梅,毛银,叶乘锋,张佳南,娜荷芽,汪敏,周宇辰。一种无需诱导剂提高大肠杆菌中乙醇酸产量的方法,ZL202010646581.1,2022/4/15

 

三、承担教学科研项目情况

1.     江苏省杰出青年基金项目,食品二元羧酸生物传感器理性设计与调控机制研究,项目编号SBK2022010219,20227-20256月,经费150万元,项目主持;

2.     广西重点研发计划,微生物发酵粕关键技术研究及产业化应用,项目编号:桂科AB22035063,20221-202412月,经费199万元,项目主持;

3.     天津市合成生物技术创新能力提升行动2020年度科技攻关,己二酸生物合成关键技术研究,项目编号 TSBICIP-KJGG-015-03,20211-202312月,经费80万元,项目主持;

4.     国家重点研发计划课题,活性污泥底盘细胞的设计及污染物高效降解菌的构建,项目编号 2019YFA0905502,20201-202412月,经费468万元,课题负责人;

5.     国家自然科学基金-面上项目,平衡大肠杆菌代谢流量分配高效积累乙醇酸,项目编号 21877053,20191-202212月,经费67万元,项目主持;

6.     2017年江苏省“双创计划”,300万元,项目主持。

7.     国家自然科学基金-青年项目,乙醇酸合成途径基因在大肠杆菌中的模块化协调表达,项目编号 31500070,20161-201812月,经费20万元,项目主持;

8.     2015年江苏特聘教授项目,50万元,项目主持;

9.     2016年江苏省“双创人才”高校创新,32万元,项目主持;

10.  江苏省自然科学基金-青年项目,代谢改造大肠杆菌高效积累乙醇酸的分子机理研究,项目编号BK20150136, 20157-20186月,经费:20万元,项目主持;

11.  江南大学自主科研-重点项目,代谢改造大肠杆菌高效积累葡萄糖二酸,20171-11.201912月,100万元,项目主持。

12.  2016年江苏省六大人才高峰,8万元,项目主持。

13.  横向科研,到账745万元,项目主持。

 

四、获奖情况(含指导学生获奖)

1. 江苏特聘教授,2015

2. 江苏省“双创人才”,2016

3. 江苏双创团队,2017

4. 江苏省“六大人才高峰”,2016

5. 无锡市社会事业领军人才,2015

6. 江南大学至善青年学者,2016, 2017

7. 粮油学会玉米深加工分会理事,2018

8. 江苏省杰出青年获得者,2022

9. 江南大学优秀毕业论文指导教师,2018

10. 全国大学生生命科学创新创业大赛指导教师,2019,2020

 

以上资料更新时间截止:20229


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